Quote:
Originally Posted by ChrisK
Since I am also homozygous for geekness...loss of 1 or 2 bp leads to loss of function because reading frame changes. Loss of 3 consecutive bases (or multiple thereof) would not necessarily do so as reading frame is maintained, and proteins often retain function with this type of mutation. Same goes for insertion of bases.
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Chris - thus my almost always qualifier. A frameshift mutation is a no brainer loss of function, deletion of one or more amino acids (one or more sets of 3bp deletions) may or may not, depending on whether the amino acid deletion(s) is/are in a critical region of the protein.