In general, I find there are some folks who enjoy doing science experiments as much as growing tomatoes. I get that it could be fun. haha.
However, my "common sense" approach to vegetable gardening (and tomatoes) usually works out fine...with a little knowledge/experience mixed in. My seedlings have been growing fine with a quality potting mix or seed starter mix....either one. Part of the fun of doing anything (in my opinion) is getting better. This is where knowledge/experience/science comes in. The journey is the fun!