If you don't have serious fusarium or bacterial wilt problems then Big Beef works very good as a root stock. It gives some protection from both fusarium and RKN and it grafts well. It has little or no affect on the growth habit of the heirloom grafted to it so if you are looking for some boost in size or vigor from grafting and not mild disease help then I would pick out several of the available true root stock seeds and try them. Some will give you much larger more vigorous plants and some will help with fruit size and some will help with production. You will have to experiment some to find the one that works best with the heirlooms you wish to grow and see which gives you the best results in your garden conditions.
For me RST-04-106-T has proven itself to be the best root stock overall for dealing with my awful soil born diseases. If you don't have to deal with three races of fusarium and bacterial wilt then there are many available root stock varieties available to try.
Bill
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