I have read that neem is the least clogging of all horticultural oils, but clogging the stomata could be an issue with regular spraying. I don't spray more than twice a week, and ideally I spray something else in-between, like compost tea.
Also if you are using a premixed neem product, what else is in there? Chemical solvents to keep it in a liquid state at cooler temperatures? You can get a quart of cold-pressed neem for around $20, a 1 gallon pump sprayer for $10, and natural dish soap for a few bucks. A quart of neem oil lasts me years.
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