We dealt with a friends small garden plot maybe 2 to 300 square feet in the same way as Karen said - by weeding as much as we could and then spreading deep mulch, in our case I would say about three to four inches of wood mulch. We then planted some perennial flowers - not many - into the plot just to give it a nice look for the meantime. This was about three or four years ago. It worked in a year. The plot is much healthier than it was before, much more fertile, and I think it's safe to say the weeds are almost gone. I forgot the name of the weeds but they were similar to Canada thistle. They spread via rhizomes.
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